ARCHETYPE Examination of a cleavage-stage embryo (openEHR-EHR-CLUSTER.exam_embryo.v1)

ARCHETYPE IDopenEHR-EHR-CLUSTER.exam_embryo.v1
ConceptExamination of a cleavage-stage embryo
DescriptionMorphological findings obtained by microscopy of the human cleavage-stage embryo.
UseUse to record morphological observations appropriate for the cleavage-stage of human embryo development, usually as part of assisted reproduction treatment. This archetype has been specifically designed to be used in the 'Observations detail' SLOT within the 'OBSERVATION.embryo_assessment' or 'ACTION.procedure' archetype, but can also be used within other ENTRY or CLUSTER archetypes, where clinically appropriate.
MisuseNot to be used for recording observations on oocytes, zygotes and blastocysts - use specific CLUSTER archetypes for this purpose.
PurposeTo record structured observations about a human cleavage-stage embryo.
ReferencesAlpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283.

Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71.
Copyright© openEHR Foundation
AuthorsAuthor name: Peter Fedorcsak
Organisation: Oslo University Hospital
Email: peter.fedorcsak@medisin.uio.no
Date originally authored: 2021-10-26
Other Details LanguageAuthor name: Peter Fedorcsak
Organisation: Oslo University Hospital
Email: peter.fedorcsak@medisin.uio.no
Date originally authored: 2021-10-26
OtherDetails Language Independent{licence=This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/., custodian_organisation=openEHR Foundation, references=Alpha Scientists in Reproductive, M. and E.S.I.G.o. Embryology, The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction, 2011. 26(6): p. 1270-1283. Prados, F.J., et al., The cleavage stage embryo. Human Reproduction, 2012. 27(suppl_1): p. i50-i71., original_namespace=org.openehr, original_publisher=openEHR Foundation, custodian_namespace=org.openehr, MD5-CAM-1.0.1=31EAAB7D52805EA5BA18B731984C63AB, build_uid=1aa426dc-7e70-4a2e-a7f4-2cef23bfe983, ip_acknowledgements=This artefact includes content from SNOMED Clinical Terms® (SNOMED CT®) which is copyrighted material of the International Health Terminology Standards Development Organisation (IHTSDO). Where an implementation of this artefact makes use of SNOMED CT content, the implementer must have the appropriate SNOMED CT Affiliate license - for more information contact https://www.snomed.org/snomed-ct/get-snomed or info@snomed.org., revision=1.0.0}
Keywordsin vitro, fertilization, IVF, reproductive medicine, zygote, fertilised, fertilized, oocyte, egg, fertilisation, embryo, reproduction, ART, blastocyst
Lifecyclepublished
UID6f3d8069-611c-43c5-a30d-a583c71b5850
Language useden
Citeable Identifier1013.1.5828
Revision Number1.0.0
AllArchetype [runtimeNameConstraintForConceptName=null, archetypeConceptBinding=null, archetypeConceptDescription=Morphological findings obtained by microscopy of the human cleavage-stage embryo., archetypeConceptComment=null, otherContributors=Vebjørn Arntzen, Oslo University Hospital, Norway (openEHR Editor)
SB Bhattacharyya, Bhattacharyyas Clinical Records Research & Informatics LLP, India
Peter Fedorcsak, University of Oslo, Norway (openEHR Editor)
Rosane Gotardo, Systema Ltda., Brazil
Heather Grain, Llewelyn Grain Informatics, Australia
Gareth Greggains, Oslo University Hospital
Evelyn Hovenga, EJSH Consulting, Australia
Liv Laugen, ​Oslo University Hospital, Norway, Norway (openEHR Editor)
Heather Leslie, Atomica Informatics, Australia (openEHR Editor)
Manisha Mantri, C-DAC, India
Mikael Nyström, Cambio Healthcare Systems AB, Sweden
Bjørn Næss, DIPS ASA, Norway
Trine Skuland, Oslo University Hospital
Norwegian Review Summary, Nasjonal IKT HF, Norway
John Tore Valand, Haukeland Universitetssjukehus, Norway
Julius Hreinsson, Laboratory Director at Reproductive Medicine, Sahlgrenska University Hospital, Sweden, originalLanguage=en, translators=Norwegian Bokmål: Peter Fedorcsak, Vebjørn Arntzen, University of Oslo, Oslo University Hospital, peterfe@uio.no, varntzen@ous-hf.no
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    • None [Absence of cytoplasmic fragments.]
    • Mild fragmentation [Cytoplasmic fragments cover < 10% of the total cytoplasmic volume.]
    • Moderate fragmentation [Cytoplasmic fragments cover 10 - 25% of the total cytoplasmic volume.]
    • Severe fragmentation [Cytoplasmic fragments cover > 25% of the total cytoplasmic volume.]
  •  Text
  •  Proportion
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    • Equal, stage specific [Equally sized blastomeres, stage specific cell size.]
    • Unequal, stage specific [Unequally sized blastomeres, stage specific cell size.]
    • Equal, non-stage specific [Equally sized blastomeres, non-stage specific cell size.]
    • Unequal, non-stage specific [Unequally sized blastomeres, non-stage specific cell size.]
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  •  Coded Text
    • No visible nuclei [Nuclei are not visible.]
    • Mononucleation [Only a single visible nucleus in all blastomeres.]
    • Binucleation [Two visible nuclei in one blastomere.]
    • Multinucleation [Multiple visible nuclei in one blastomere.]
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  •  Coded Text
    • None [Absence of compaction.]
    • Minimal [Less than 50% of the total embryonic volume is compacted.]
    • Moderate [Over 50% of the total embryonic volume is compacted.]
    • Complete [The complete volume of the embryo is compacted.]
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    • None [Absence of cytoplasmic fragments.]
    • Mild fragmentation [Cytoplasmic fragments cover < 10% of the total cytoplasmic volume.]
    • Moderate fragmentation [Cytoplasmic fragments cover 10 - 25% of the total cytoplasmic volume.]
    • Severe fragmentation [Cytoplasmic fragments cover > 25% of the total cytoplasmic volume.]
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  •  Proportion
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    • Equal, stage specific [Equally sized blastomeres, stage specific cell size.]
    • Unequal, stage specific [Unequally sized blastomeres, stage specific cell size.]
    • Equal, non-stage specific [Equally sized blastomeres, non-stage specific cell size.]
    • Unequal, non-stage specific [Unequally sized blastomeres, non-stage specific cell size.]
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    • No visible nuclei [Nuclei are not visible.]
    • Mononucleation [Only a single visible nucleus in all blastomeres.]
    • Binucleation [Two visible nuclei in one blastomere.]
    • Multinucleation [Multiple visible nuclei in one blastomere.]
    • Broad multinucleation [Two or more visible nuclei in two or more blastomeres.]
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    • None [Absence of compaction.]
    • Minimal [Less than 50% of the total embryonic volume is compacted.]
    • Moderate [Over 50% of the total embryonic volume is compacted.]
    • Complete [The complete volume of the embryo is compacted.]
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