ARCHETYPE HScore (openEHR-EHR-OBSERVATION.hscore.v0)

ARCHETYPE IDopenEHR-EHR-OBSERVATION.hscore.v0
ConceptHScore
DescriptionEstimate an individual's risk of having reactive hemophagocytic syndrome.
UseUse to record an estimation of an individual's risk of having reactive hemophagocytic syndrome.
PurposeTo record an estimation of an individual's risk of having reactive hemophagocytic syndrome.
ReferencesFardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690. PubMed PMID: 24782338.

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 16;. doi: 10.1016/S0140-6736(20)30628-0. [Epub ahead of print] PubMed PMID: 32192578.
AuthorsAuthor name: Liv Laugen
Organisation: Oslo universitetssykehus
Email: liv.laugen@ous-hf.no
Date originally authored: 2020-03-30
Other Details LanguageAuthor name: Liv Laugen
Organisation: Oslo universitetssykehus
Email: liv.laugen@ous-hf.no
Date originally authored: 2020-03-30
OtherDetails Language Independent{licence=This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/4.0/., custodian_organisation=openEHR Foundation, references=Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690. PubMed PMID: 24782338. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 16;. doi: 10.1016/S0140-6736(20)30628-0. [Epub ahead of print] PubMed PMID: 32192578. , original_namespace=org.openehr, original_publisher=openEHR Foundation, custodian_namespace=org.openehr, MD5-CAM-1.0.1=2F7A9970BE5A959CEFD5211DB1907494, build_uid=b0a5f2b4-f7a1-43fd-ac35-a3a392df19f8, revision=0.0.1-alpha}
KeywordsHLH, Hemophagocytic lymphohistiocytosis, COVID-19, infection,
Lifecyclein_development
UID677a2484-3ebd-49c9-81fc-b8341fae7a33
Language useden
Citeable Identifier1013.1.4548
Revision Number0.0.1-alpha
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Vebjørn Arntzen, Oslo university hospital, Norway
Silje Ljosland Bakke, Helse Vest IKT AS, Norway
Marit Alice Venheim, Helse Vest IKT AS, Norway, originalLanguage=en, translators=
  • Norwegian Bokmål: Marit Alice Venheim, Helse Vest IKT, marit.alice.venheim@helse-vest-ikt.no

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    33: 38.4-39.4°C [The body temperature of the individual is between 38.4 and 39.4°C.]
    49: >39.4°C [The body temperature of the individual is greater than 39.4°C.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0008], code=at0008, itemType=ELEMENT, level=4, text=Organomegaly, description=Findings of any enlargement of the liver or/and spleen in the individual., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: None [No enlargement of the liver or the spleen.]
    23: Hepatomegaly or splenomegaly [Enlargment of the liver or the spleen.]
    38: Hepatomegaly and splenomegaly [Enlargement of both the liver and the spleen.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0012], code=at0012, itemType=ELEMENT, level=4, text=Number of cytopenias, description=Number of cytopenias present - in red cells, white cells and/or platelets., comment=Defined as either haemoglobin concentration of 9.2 g/dL or less (≤5.71 mmol/L), a white blood cell count of 5000 white blood cells per mm³ (5,0 x 10E9/L) or less, or platelet count of 110 000 platelets per mm³ (110 x 10E9/L) or less, or all of these criteria combined. , uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: One lineage [Cytopenia in only one cell lineage.]
    24: Two lineages [Cytopenia in two cell lineages.]
    34: Three lineages [Cytopenia in three cell lineages.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0016], code=at0016, itemType=ELEMENT, level=4, text=Triglycerides, description=The triglycerides category, measured in mmol/L or mg/dL., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: <1.5 mmol/L [The Triglyceride level is less than 1.5 mmol/L or 132.7 mg/dL.]
    44: 1.5-4.0 mmol/L [The Triglyceride level is 1.5-4.0 mmol/L or 132.7-354 mg/dL.]
    64: >4.0 mmol/L [The Triglyceride level is greater than 4.0 mmol/L or 354 mg/dL.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0017], code=at0017, itemType=ELEMENT, level=4, text=Fibrinogen, description=The fibrinogen category, measured in g/L or mg/dL., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: >2.5 g/L [The fibinogen level is greater than 2.5 g/L or 250 mg/dL.]
    30: ≤2.5 g/L [The fibinogen level is less than or equal to 2.5 g/L 250 mg/dL.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0018], code=at0018, itemType=ELEMENT, level=4, text=Ferritin, description=The ferritin category, measured in ng/mL or μg/L., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: <2000 ng/ml [The ferritin level is less than 2000 ng/ml or 2000 μg/L.]
    35: 2000–6000 ng/ml [The ferritin level is 2000-6000 ng/ml or 2000-6000 μg/L.]
    50: >6000 ng/ml [The ferritin level is greater than 6000 ng/ml or 6000 μg/L.]
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    19: ≥30 U/L [The aspartate aminotransferase level is greater than or equal to 30 U/L.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0020], code=at0020, itemType=ELEMENT, level=4, text=Haemophagocytosis on bone marrow aspirate, description=Presence of hemophagocytosis features in bone marrow aspirate., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: No [No hemophagocytosis features are present in bone marrow aspirate.]
    35: Yes [Hemophagocytosis features are present in bone marrow aspirate.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0021], code=at0021, itemType=ELEMENT, level=4, text=Known immunosuppression, description=Presence of known underlying immunosuppression., comment=For example HIV positive or receiving long-term immunosuppressive therapy., uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=C_DV_ORDINAL, bindings=null, values=0: No [No known underlying immunosuppression.]
    18: Yes [Known underlying immunosuppression.]
    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0036], code=at0036, itemType=ELEMENT, level=4, text=Total HScore, description=The total sum for each component variable for the HScore., comment=null, uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=DV_COUNT, bindings=null, values=min: >=0; max: <=337

    , extendedValues=null], ResourceSimplifiedHierarchyItem [path=/data[at0001]/events[at0002]/data[at0003]/items[at0037], code=at0037, itemType=ELEMENT, level=4, text=Probability of HS, description=Probability of an individual having reactive hemophagocytic syndrome., comment=According to table 5 in the original original paper by Fardet et al, https://doi.org/10.1002/art.38690., uncommonOntologyItems=null, occurencesFormal=0..1, occurencesText=Optional, cardinalityFormal=null, cardinalityText=null, subCardinalityFormal=null, subCardinalityText=null, dataType=DV_PROPORTION, bindings=null, values=
    • Percent
    Numerator: 0.0..100.0
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